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It is noteworthy that pre-mutation carriers often develop a neurodegenerative disorder called the Fragile X-associated Tremor/Ataxia Syndrome (FXTAS, Figure 2), which presents with neurodegeneration, parkinsonism and brain atrophy, and which is associated with primary ovarian insufficiency in females (reviewed in Botta-Orfila et al., 2016

[DOI] [PMC free article] [PubMed] [Google Scholar] 292.Finamore A, Massimi M, Conti Devirgiliis L, Mengheri E

Eur Respir Soc De Benedetto F, Pastorelli R, Ferrario M, de Blasio F, Marinari S, Brunelli L, Wouters EF, Polverino F, Celli BR (2018) Supplementation with Qter and Creatine improves functional performance in COPD patients on long term oxygen therapy

Stem Cell Int 2021, 2130727

The gut microbiota participates in regulating the integrity and function of the intestinal barrier in a homeostatic balance

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