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Reviews in Endocrine and Metabolic Disorders, 23(5), 979994

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Keap1, an E3 ubiquitin ligase and an inhibitor of the transcription factor nuclear erythroid-related factor 2 (NRF2), has recently been identified as a target of protein succination and consequent inactivation, which led to the induction of NRF2 and a potent antioxidant response 5,7

It is typically caused by distal renal tubular acidosis, hypokalemia, bowel dysfunction, and a high-protein, low-alkali diet

They also play a vital role in maintaining healthy nervous system function and are necessary for healthy skin, hair, eyes, and liver

Journal of Proteome Research, 19 , 29422949