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Keler, M., Wittig, I., Ackermann, J

Katzke, Verena

[13] In the setting of acute isoniazid overdose or toxicity, extraordinarily high doses of pyridoxine are used as an antidote: the recommended approach is to administer pyridoxine in a total amount equal to the amount of isoniazid ingested

Conversely, elevated -syn inhibits intracellular trafficking and lysosomal function of normal GCase in neurons, indicating the presence of a bidirectional pathologic loop between GCase and -syn in PD and other synucleinopathies (Aflaki et al