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61 This unique cell death pattern, triggered by iron-dependent peroxidation of phospholipids, is governed by many cellular metabolic pathways, including the redox balance, mitochondrial function, amino acids metabolism, blood lipids, and glucose metabolism

This morphological variability likely affects mitochondrial functions, such as ATP production and Ca 2+ buffering

doi: 10.1021/acs.jcim.5b00529 McCarthy, Claudia A., Rash, Lachlan D., Chassagnon, Irene R., King, Glenn F

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(2015) Dimethyl fumarate induces necroptosis in colon cancer cells through GSH depletion/ROS increase/MAPKs activation pathway, Br