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M.LeeS.HanH

For Supplementary Fig

* Correspondence: Youjun Mi, [email protected] Tan, [email protected] These authors have contributed equally to this work and share first authorship Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

A lot of the studies: Are small Have a high risk for bias (poor reporting/inconsistency/blinding/etc) Show mixed results (heterogeneity) Often the studies arent even looking at the same thing: One study might look at PCOS patients, another at endometriosis patients Another might use 800 ug of folate instead of 400 ug Some might combine different supplements instead of just one So its hard to make strong conclusions

We don't just put an ingredient on a label

Relative contributions of diabetes and chronic kidney disease to neuropathy development in diabetic nephropathy patients