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790 To address these challenges, a deeper understanding of the intracellular trafficking mechanisms is required

Overall, existing studies suggest that microbial metabolites may act as multifunctional neuroprotective modulators, influencing metabolic, epigenetic, immunological, and barrier-stabilizing processes, with potential relevance for modifying neurodegenerative disease progression [148]

In early AKI, ferroptosis-mediated elimination of irreversibly damaged PT cells may limit oxidative stress propagation and promote tissue repair, which is supported by studies showing that transient ferroptosis induction reduces AKI severity in mouse models (287, 288)