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doi: 10.1084/jem.20052398 46 McDevittM

In this process, NE-mediated activation of the inhibitory 2-adrenergic receptors lead to lowered Ca 2+ -channel activation and promote hyperpolarization, to reduce chronic pain 5

Andresen E, Resch-Genger U, Schaferling M

Two of the three are not classical peptides at all, which is the first thing worth clearing up

The peptide's combined sleep-promoting and analgesic properties may be particularly relevant for pain conditions where sleep disruption exacerbates pain perception in a vicious cycle