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System X c , a cystine/glutamate antiporter composed of solute carrier family 7 member 11 (SLC7A11/xCT) and solute carrier family 3 member 2 (SLC3A2), mediates the import of extracellular cystine, which is subsequently reduced to cysteine for GSH synthesis ( c or GPX4 disrupts cellular redox homeostasis, leading to ROS accumulation and unchecked LPO, ultimately triggering ferroptotic cell death

Ann Thorac Surg 73(6):1950-1, 2002

Pulmonary sarcoid-like granulomatosis induced by ipilimumab

Polydatin ameliorates renal ischemia/reperfusion injury by decreasing apoptosis and oxidative stress through activating sonic hedgehog signaling pathway

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A phase III clinical trial to evaluate the safety and immunogenicity of 23-valent pneumococcal polysaccharide vaccine (PPV23) in healthy children, adults, and elderly