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Similarly, a study by Zhou et al

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Pathway-based classification of glioblastoma uncovers a mitochondrial subtype with therapeutic vulnerabilities

CD4 + , CD8 + , and T cells drive inflammation and activate HSCs, which in turn regulate T cell differentiation and proliferation

PCAF-mediated acetylation of LDHB at K82 was found to significantly decrease its enzymatic activity and impair hepatic lactate clearance, resulting in lactate accumulation, which exacerbates lipid deposition and inflammatory responses by activating histone hyperacetylation in high-fat diet (HFD)-induced NAFLD