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5 Natural flavonoids as ferroptosis inhibitors for the therapy of CNS diseases Flavonoids are one of the largest classes of plant polyphenols, characterized by a C6-C3-C6 backbone consisting of three rings labeled as A, B, and C (Dias et al., 2021)

Acknowledgments This research has been funded by the Swedish Research Council Formas and the Spanish FIS FEDER (13/1944)

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In summary, the activation of microglia and astrocytes, and the subsequent release of pro-inflammatory cytokines and ROS, create an unfavorable environment for neuronal damage and death