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doi: 10.1038/s41580-018-0008-z 223 RayonTStamatakiDPerez-CarrascoRGarcia-PerezLBarringtonCMelchiondaMet al

Redox Signal 24 , 299311 (2016)

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One modulates an enzyme, the other activates a receptor

In RABGAP1 KD i3 neurons, the reduction in C99 levels suggests a likely decrease in the pool of APP localised within early endosomes, where BACE1 activity is enriched