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The major role of OCTN2 in carnitine absorption and tissue distribution is demonstrated by the existence of a human disease caused by inborn defects of the OCTN2 gene, namely PCD (Magoulas and El-Hattab, 2012)

Beneficial effects of UA, including antioxidant activity, are believed to be mediated through the activation of the Nrf2/Kelch-like ECH-associated protein 1 (Keap1) signaling pathway [45]

The hyperlipoproteinemias can be subdivided into hypercholesterolemia, hypertriglyceridemia, and combined hyperlipidemia, with elevations of both cholesterol and triglycerides