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Science 369 , eaay5356 (2020)

With treatment, people usually fare well unless the disease was advanced when it was diagnosed

Currently, its annual average concentration is leveling off in the USA and Europe but continues to increase in Asia

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This includes the downregulation of Bax (a pro-apoptotic marker), upregulation of Bcl-2 (an anti-apoptotic protein), and increased expression of proliferating cell nuclear antigen (PCNA), a key marker of cell proliferation [65]