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Li, W., He, Y., Zhang, R., Zheng, G

10.3233/JAD-2008-15314 54 KaulaskarS.BhutadaP.RahigudeA.JainD.HarleU

As kidney function declines, mortality and comorbidities, particularly cardiovascular complications, rise steadily (1)

We hypothesize that this mutation could promote a more stable interaction of KEAP1 with Cul3, increasing NRF2 degradation and explaining the lower levels in this cell line