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But the logic can falter when extended too widely, said Grossman

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In this state, fibroblasts synthesize fewer ECM proteins, while matrix-degrading metalloproteinases increase, further exacerbating the imbalance in ECM homeostasis and perpetuating the cycle of collagen fiber fragmentation

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Amantadine was the first pharmaceutical agent studied for the treatment of fatigue in MS, and several randomized controlled trials (RCTs) have shown that amantadine can reduce fatigue in people with MS

Folate depletion changes gene expression of fatty acid metabolism, DNA synthesis, and circadian cycle in male mice