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Epigenetic regulation of sex-specific hepatic gene expression Another key factor influencing liver metabolism and HCC is epigenetics, encompassing global DNA hypomethylation of oncogenes, hypermethylation of tumor suppressors, histone modifications that alter chromatin accessibility, chromatin-loop rearrangements facilitating enhancerpromoter oncogenic interactions, and post-transcriptional regulation via microRNAs and RNA modifications [144]

Supplementary Table 3

Dietary-lifestyle patterns and colorectal cancer risk: global cancer update programme (CUP global) systematic literature review

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In contrast, salinity modifies both osmotic potential and soil chemistry, generating ionic constraints such as Na and Cl toxicity, competition with essential nutrients, and impaired membrane transport selectivity