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The primary manufacturing hubs are in China (Guangdong province is a major center) and South Korea

Thus, when given normal doses of azathioprine or 6-MP, these patients with reduced or absent TPMT activity can develop seriously low white blood cell counts for prolonged periods, exposing them to serious life-threatening infections

As a short tripeptide, Pinealon is rapidly metabolized into its constituent amino acids, which contributes to its favorable tolerability profile in experimental models