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A 2022 meta-analysis in Antioxidants found that NAC supplementation (a glutathione precursor) modestly improved HOMA-IR (insulin resistance) in adults with metabolic syndrome, though the effect size was small (Cohen's d = 0.31)

Viral infections, like SARS-CoV-2 that cause COVID-19, can induce massive reactive oxygen species (ROS) that lead to severe tissue injury

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doi: 10.1007/978-3-319-75402-4_2 95

However, the damaging effects of ROS cannot be overlooked

This means that without the increased energy needs induced by exercise, carnitines ability to accelerate fat burning and promote weight loss is limited