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The pathophysiology of severe asthma with persistent airflow limitation shares similar features with that of chronic obstructive pulmonary disease (COPD), including airway remodeling and emphysema-like changes, which complicate diagnosis and treatment [42]

10.1016/j.ejpb.2018.07.025 58 FanenP.Wohlhuter-HaddadA.HinzpeterA

Regulation of pro-inflammatory responses by lipoxygenases via intracellular reactive oxygen species in vitro and in vivo

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In Beclin1-deficient HCT116 colonic epithelial cells, the expression level of LRRK2 is elevated, suggesting that autophagy inhibition may upregulate LRRK2