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The lack of group difference in this study contrasts with some prior literature, which has found that rural and Appalachian populations often experience lower levels of care utilization and help-seeking 27

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Even if small cardiovascular benefits exist in certain populations, they must now be weighed against established cancer risk

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Additionally, processes directly linked to host-microbiota interactions, including bacteria-associated processes defense processes and inflammatory processes, demonstrated a higher enrichment fold change in humans while in mice these processes had a decreased enrichment fold change

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