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Future studies should use lower doses to determine the threshold concentration of B12 in the gut necessary to change the activities of the microbiota, particularly in the Lachnospiraceae populations and how these changes impact microbe-host interactions in the gut with a specific focus on IL-12p40 cytokine production along the GI tract

Eisner V, Cupo RR, Gao E, Csordas G, Slovinsky WS, Paillard M, et al

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Also, keep the pen away from the cooling part of the fridge (usually at the back or top of the fridge), because it might get too cold or even freeze