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For example, in one trial, about 65% of children on Pycnogenol had significant improvement vs 9% on placebo

Additionally, several studies indicate that although most metabolic changes show common trends in both UC and CD, distinct patterns can also be identified: for example, alterations in the bile acid pool, such as differential shifts in primary versus secondary bile acids

It is, therefore, largely unexplored in terms of simulations, measurement techniques, modeling, data analysis, and in-vivo tests

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