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Those reports suggested a MTHFR polymorphism independent mechanism in aging and cell-type specific global DNA methylation

This is because the gut can degrade a significant portion of ingested nutrients

ACS Chem Neurosci 2016

Kopitz, J., Holz, F

Given the close association between NAFLD and metabolic dysfunction, a panel of experts proposed in 2020, not without some controversy, to rename this condition as metabolic-(dysfunction) associated fatty liver disease (4)