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Description

Clin Oral Investig 7: 103-107

Part of this migratory effect can be attributed to the stimulation of IL-1 secretion by resident macrophages via MSU crystals, which subsequently instigates caspase-11 expression in macrophages through IL-1R and MYD88 ( sUA triggers macrophage migration indirectly

Rosiglitazone (RGL), a synthetic agonist of PPAR (a key factor in fatty acid oxidation), can inhibit the secretion of chemokines and the activation of nuclear factor-B (NF-B) in human renal proximal tubular cells (PTCs) by activating PPAR SUMOylation, thereby suppressing inflammation and improving RF [81]