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doi: 10.3389/fphar.2026.1681783 Received 07 August 2025 Revised 27 December 2025 Accepted 08 January 2026 Published 02 February 2026 Volume 17 - 2026 Edited by Mojgan Rastegar, University of Manitoba, Canada Reviewed by Mahmoud Sabra, Assiut University, Egypt Linda Piras, Sapienza University of Rome, Italy Updates Copyright 2026 Khinchin, Rakoubian, Romano, Ryan, Yarbro, Kobayashi and Liang

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Meta-analysis of observational studies

MEOS uses a different enzyme (Cytochrome P450 2E1 - CYP2E1) to metabolize ethanol, but still creates toxic acetaldehyde

Initially, acetyl-CoA is converted to malonyl-CoA by acetyl-CoA carboxylase (ACC) and malonyl-CoA is then converted to palmitate by fatty acid synthase (FASN)

At this stage, when normal mice see two mice in the two side chambers, they spend more time with the novel mouse than with the older mouse