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Although the available in vivo literature on BBB permeability would predict a disruptive effect of nicotine (Hawkins et al., 2004), this finding was determined following chronic subcutaneous dosing and other work has demonstrated a rebound inflammatory effect following this mode of exposure (Saravia et al., 2019)

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Regardless of the consumption method, nicotine is primarily metabolized in the liver and excreted through the kidneys via urine, though cotinine can be detected in all major body fluids and hair

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