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Similar content being viewed by others Introduction Ischemic stroke transcends its identity as a vascular emergency, emerging instead as a systemic metabolic epicenter where cellular survival strategies collide with catastrophic systemic dysregulation, irrevocably reshaping human behavior, cognition, and psychosocial resilience [1,2,3,4,5]

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Viswanathan M, Patnode CD, Berkman ND et al (2017) Assessing the risk of bias of individual studies in systematic reviews of health care interventions