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This review aims to provide a comprehensive overview of the pharmaceutical properties and multi-dimensional pharmacological mechanisms of GLPS from a modern scientific perspective, summarize clinical evidence across different types of liver diseases, and objectively discuss their safety profiles, thereby providing a holistic overview to support rational clinical application and guide future research (Figure 1)

Radhakrishnan S, Menon UK, Sundaram KR

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As a result of its ability to inhibit the expression of transcription factors and pro-inflammatory cytokines such as TNF-, IL-1, IL-6, IL-8, IL-12, IL-1, and monocyte chemoattractant protein-1 (MCP-1), curcumin has demonstrated anti-inflammatory properties ( Supplementary Table 1 )

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