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It is notable for its remarkable stability compared to many other endogenous peptides

Then the dominoes: the LIFT-AD trial failed in September 2024, the Department of Justice settlement landed in January 2025, and the formal retractions of two foundational papers followed in April 2025

doi: 10.1096/fj.05-5016fje

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Looking forward, the future of SFN research lies in well-designed, biomarker-stratified clinical trials that incorporate advanced formulations and consider the complex interplay between diet, host genetics, and gut microbiota