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Figure 5 3.4.1 Macrophages In response to environmental stimuli, macrophages can polarize into different phenotypes, demonstrating their extraordinary adaptability

242 The DHODH-mediated pathway The flavin-dependent mitochondrial enzyme DHODH catalyzes the de novo synthesis of pyrimidine

In fact, a recent study reported that the microbiome in ALS mice helps restrain pro-inflammatory microglia, which is opposite to what happens in AD models [219]