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To determine if Gdf11 is expressed in neuronal progenitor cells and/or mature neurons in the dentate gyrus, we performed RNAscope co-expression studies

Laboratory studies demonstrate that ES2 peptides show 3-7 times more potent senolytic activity than FOXO4-DRI in both in vitro and in vivo experimental systems, while CPP-CAND demonstrates approximately 1.2-fold higher selectivity despite shorter peptide length

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Next to assess Dihexas metabolic stability in the liver, pooled male rat liver microsomes were used