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Consistent with this finding, we found that aged female TDP-43 K408R/K408R mice were significantly more submissive to their TDP-43 +/+ counterparts in the tube test (Fig

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Inosine monophosphate dehydrogenase (IMPDH), the rate-limiting enzyme in de novo guanine nucleotide biosynthesis, has gained particular attention (Hackstein and Thomson, 2004

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