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Despite the close functional interdependence of the nervous and vascular systems, the exact mechanisms by which neurovascular dysfunction leads to neurodegeneration remain to be fully elucidated (6)

Zhang W, Liu Y, Liao Y, Zhu C, Zou Z

doi: 10.3390/nu11051044

In accordance with the glutathione activator hypothesis, only positively charged amino acids replace Lys105 in enzymatically active glutaredoxins, whereas in inactive isoforms and other members of the thioredoxin superfamily the activator candidate is often separated from the catalytic cysteine residue in the primary sequence or is replaced by uncharged residues 3,11,12 (Fig

Glutathione levels also decrease naturally as a result of aging