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However, considering therapeutic strategies that target cancer cell metabolism alone is not sufficient because metabolic rewiring affects the composition, phenotype and function of cancer cells and microenvironmental components

see Table 1) (McGuire, 2010)

Nat Biotechnol 18:208212

Zhang C, Huang Y, Zheng F, Zeljic K, Pan J, Sun B

Options include medication, physical therapy, exercise, heat therapy (including microwave and ultrasound), orthotics and assistive devices, and rest

they assessed the effectiveness of the frailty using physical function, body composition and physical and cognitive function, with less focus on frailty biomarkers