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Although essential for neuroprotection, the barrier restricts the entry of many therapeutic molecules, including hydrophilic drugs and large biomolecules, thereby limiting treatment options for neurological disorders [47]

84 The initial hypothesis that inducible nitric oxide synthase (iNOS) in Kupffer cells is a significant source of NO formation 85 was quickly dismissed, as iNOS was not consistently induced in different models 86 and iNOS inhibitors did not provide protection

Ginkgo biloba B treatment has an inhibitory effect on lipid accumulation and ferroptosis caused by oxidative stress in MAFLD, possibly through the activation of the Nrf2 pathway, exerting an antioxidant effect

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After that, succinate is catalyzed by succinate dehydrogenase (SDH) to produce fumarate, then via fumarase (FH) to produce malate

Membranes were washed three times for 10 min each in Tris-buffered saline (Cat