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While short term implementation of ketogenic diets has shown potential in several neurodegenerative diseases for improving metabolic function and producing neuroprotective and anti-inflammatory intermediates [99], long-term implementation is limited by decreased patient adherence and occasional adverse cardiac, renal and cognitive events (particularly in pediatric patients) [100]

Neuropathy in diabetes

Mol Cell Biol 2000

Kaempferol (Figure 2D) and fisetin (Figure 2E) are also examples of flavonoids investigated for GST inhibition properties in animal cells, specifically in tumor or cancer research

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As a result of promising findings in animal models (see Neuroprotective activity), a few recent clinical trials have examined the effect of oral curcumin supplementation on cognition in healthy older adults and AD patients (57)