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36 As 85% of aconitase in the brain is the mitochondrial isozyme, a decrease in brain aconitase activity is considered a sensitive indicator of excess mitochondrial superoxide production

The foundational study is Neelakantan and colleagues, 2018 , in Biochemical Pharmacology

Similarly, glucose excretion was also reduced in mice co-treated with metformin and STF-31 compared with that in metformin-only-treated mice (Fig

And that's it

The combination of both drugs significantly reduced the production of acetate (Fig

Similar content being viewed by others Facts GSH system is one of the important endogenous antioxidant systems, which can maintain cellular redox balance and prevent oxidative damage and cell death