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Additionally, recent studies have found that the expression of GPX4 and GSH was disordered in rats administered DOX [92]

10.3389/fimmu.2020.00583 Front Immunol

While the treatment with Ru(II)-OH or NP2 slightly elevated the ROS levels inside the hypoxic cancer cells, the treatment with NP4 showed a strong enhancement of ROS

[33] Although the enzyme is functionally limited to the conversion of superoxide radicals into less toxic oxygen-containing molecules, methodological approaches utilizing phylogenetic and structural protein analysis suggest that three SOD isoforms have evolved independently to combat superoxide accumulation

elegans can be extended by superoxide/catalase mimetics suggesting that oxidative stress is a major determinant of the rate of aging