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Antigen-activated aged T cells and anti-tumour T cells share notable dysfunctions: both display metabolic issues, decreased mitochondrial function, and increased expression of inhibitory receptors such as PD-1 and cytotoxic T-lymphocyte antigen 4 (CTLA-4), further diminishing immune activity (Zhang et al, 2020)

Int J Plant Environ 6:264269

doi: 10.1016/j.jana.2014.04.005 32 FrewPMParkerKVoLHaleyDOLearyADialloDDet al

Overexpression of phospholipase C in keratinocytes upregulates cytokine expression and causes dermatitis with acanthosis and T-cell infiltration

To this end, researchers have developed or screened a range of drugs and compounds capable of inhibiting ferroptosis through various approaches and have validated their neuroprotective effects using various disease models (Table III)