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These models are capable of more effectively recreating the multicellular architecture and cell-to-cell interactions, being a more reliable and versatile technique for the study of several complex mechanisms of disease [89]

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However, when these resources are exhausted, the toxic pathway may prevail, resulting in overt organ toxicity or carcinogenesis

Differentiation of Th17 cells, on the other hand, is regulated by the nuclear orphan receptor t (RORt)