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The connectivity between the nucleus accumbens and medial prefrontal cortex can predict the transition to chronic pain, and the hippocampus appears to be linked to pain exacerbation (74)

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Skin cells-microbiome interactions in basal cell and squamous carcinoma A seminal review by Dvorak proposed cancer as a wound that never heals [60], a concept later supported by multiple studies establishing a tight connection between chronic tissue injury and tumorigenesis [61]