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Safety of gold nanoparticles: from in vitro to in vivo testing array checklist

Abbreviations ACh Acetylcholine AChE Acetylcholine esterase AChR Acetylcholine receptor Akt AKT Serine/Threonine Kinase ATP Adenosine triphosphate BCL2 B cell lymphoma gene 2 CDP Cytidine-5-diphosphocholine ChAT Choline acetyltransferase CMP Cytidine monophosphate CNS Central nervous system DNA Deoxyribonucleic acid GABA Gamma aminobutyric acid GFP Green fluorescent protein ICP Intracranial pressure IOP Intraocular pressure JAK2 Janus Kinase 2 Kir3 Inwardly Rectifier K+ Channel 3 Kv7 Voltage-Gated Potassium Channel Subunit Kv7 mAChR Muscarinic acetylcholine receptor MRI Magnetic resonance imaging mRNA Messenger RNA MRS Magnetic resonance spectroscopy nAChR Nicotinic acetylcholine receptor NMDA N-methyl-D-aspartate PCYTA Choline-phosphate cytidylyltransferase A PDHA Pyruvate dehydrogenase PEMT Phosphatidylethanolamine n-methyltransferase PERG Pattern electroretinogram PI3K Phosphoinositide-3-Kinase PKC Protein kinase C PLC Phospholipase C RGC Retinal ganglion cell RNA Ribonucleic acid ROS Reactive oxygen species VEP Visual evoked potential VGCC Voltage gated calcium channel YFP Yellow fluorescent protein Footnotes Conflicts of interest: The author(s) have made the following disclosure(s): J.S.S.: Royalties e Zeiss, Dublin, CA (for intellectual property licensed by the Massachusetts Institute of Technology and Massachusetts Eye and Ear Infirmary) Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication

Quantitative analysis revealed that 30 nM AgTNPs reduced A fibril concentrations from 10 M to 0.3 M within 1 h post-NIR exposure, concurrently mitigating A-induced cytotoxicity in SH-SY5Y and BE(2)-C cells

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It causes bruising at the puncture site

Characterization of a processing protease that converts the precursor form of gamma-glutamyltranspeptidase to its subunits