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SLC7A11, a subunit of System Xc-, also plays critical roles in both ferroptosis and NAFLD/NASH pathogenesis

and reduced SIRT1 expression accompanied by miRNA alterations (Cho et al., 2015

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Second, translational tools should focus on dual-targeted nanocarriers designed to reach cerebellum and myocardiumusing TAT peptides for bloodbrain barrier penetration and CTP peptides for cardiomyocyte targetingloaded with mitochondria-directed ferroptosis modulators capable of activating GPX4 while supporting ironsulfur cluster synthesis, and released in response to GAA-repeat-dependent triggers to avoid off-target iron perturbation

The oxidized form of the molecule, GSSG, is found primarily in extracellular form

Yang, L., Li, P., Fu, S