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Phosphorylated CREB, through transcription of the brain-derived neurotrophic factor (BDNF) and its receptor TrKB, is considered the cornerstone of neurotrophin-mediated neuronal survival [86]

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Intragastric gavage of PMR caused significant elevations of serum ALT and AST activities at the 1st week (serum ALT and AST: 103.00 and 504.67 U/L for treatment group

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