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Cells that take up the target molecule of DNA (cell surface expression of membrane- associated DNA binding domains) will express the factor and have increased specific affinity for target DNA that remains extracellular, while cells that did not take up DNA will be at a competitive disadvantage as they will not bear the cell surface target DNA- specific binding domain, which is required for specifically mediated DNA uptake The method uses cell surface expression of membrane-associated DNA binding domains of, for example, transcription factors, that are encoded in the target DNA sequence, which also includes the cognate recognition sequence for the binding domain

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SIRT1, being a pivotal molecule, significantly regulates oxidative stress