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This loss of Rb function is observed in many cancers and permits tumour cell proliferation without external growth signals, representing one of the hallmarks of cancer described by Hanahan and Weinberg ( Figure 3 ) (65, 66)

doi: 10.1186/1471-2474-14-235 23

Pharmacology 93 (5-6), 278285

May 25 2016;80(6):1404-12

Chronic insomnia can exacerbate underlying conditions, creating a challenging cycle

Before conducting downstream analyses, sequences were filtered to remove all non-bacterial sequences, including archaea, mitochondria, and chloroplasts