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Studies examine: VEGFR2 activation pathways and intracellular adaptor protein recruitment Focal adhesion kinase (FAK) phosphorylation mechanisms Paxillin recruitment and integrin-actin cytoskeleton interactions Endothelial cell proliferation and migration assays in vitro Research models study the combined effects of VEGFR2-mediated proliferation and FAK-paxillin-mediated cellular motility in angiogenesis pathway investigations

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Investigations conducted on rat thoracic aorta and porcine coronary arteries have demonstrated that elevated levels of NAD + induce concentration-dependent vasorelaxation in endothelial cells (ECs) across various arterial beds