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Nishikawa M (2008) Reactive oxygen species in tumor metastasis

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In a hierarchical organization model, the SCN master clock orchestrates circadian phases in non-SCN subordinate brain clocks via rhythmic release of neurotransmitters and neuropeptides, as well as in peripheral organ clocks via systemic hormonal secretion and neural innervations, thereby coordinating rhythmic output physiology and behaviors with daily environmental changes 14 (Fig

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In the investigation of KRAS/LKB1/KEAP1 mutant lung adenocarcinoma cells, mild oxidative stress was observed to decrease NRF2 SUMOylation, which in turn enhanced the migration and invasion of these cells [132]