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However, a current limitation of microfluidic approaches is scalability: producing large batches of nanocarriers via microfluidics is challenging due to the low throughput of individual microchannels and issues like microchannel clogging (85)

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The position of the supraorbital and supratrochlear neurovascular bundles, the depth of the SMAS layer over the malar fat pad, the convexity of the zygomatic body, the trajectory of the facial artery as it crosses the mandible, the relationship of the modiolus to the oral commissure, the thickness of the platysma and its decussation pattern across the midline neck, the variant anatomy of the angular and dorsal nasal arteries near the nasal radix: all of these change the safe injection plane, the appropriate cannula or needle, the volume that can be safely deposited, and the technique angle