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Interestingly, the derived alleles of these variants that have ~100% frequency in Arctic Inuits (Figure 5) but very low in other populations, appear to compensate for this deficiency by down-regulating the omega-3/omega-6 fatty acids synthesis pathway (51)

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For kidney tissues, the control group showed normal histological structure characterized by circumscribed glomeruli with normal structure of capillary tufts and Bowman's capsule (Fig

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